The structure of the compounds synthesized was proven by spectral measurements. The reaction of N-Boc-4-aminopyrazole-5-carbaldehydes with creatinine in the presence of pyrrolidine as a catalyst in reﬂuxing acetic acid allowed to obtain 6-aminoimidazopirazolopyridines with the yields of 54 – 70 %. This method was implemented through the stage of the intermediate aminoisocyanates formation.Experimental part.

For the synthesis of their 6-oxoanalogs, the reaction of 5-aminopyrazolopyridine-6-carboxylic acids used in a modifed Curtius rearrangement with diphenylphosphorylazide was successful. It has been found that cyclocondensation of N-Boc-4-aminopyrazole-5-carbaldehydes with creatinine can be used as an eﬀective method for obtaining 6-aminoimidazopyrazolopyridines previously unknown. To develop convenient approaches to the synthesis of 6-amino- and 6-oxoimidazopyrazolopyridines as promising biologically active scaﬀolds.Results and discussion. This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.Aim. Referred to inįSTA (formerly Food Science and Technology Abstracts)Īll content is made freely available for non-commercial purposes, users are allowed to copy and redistribute the material, transform, and build upon the material as long as they cite the source. Similarity CheckĪll the submitted manuscripts are checked by the CrossRef Similarity Check. Papers are published in English.Īsk for email notification. An extensive scope of subjects in fact covers the whole of agribusiness, that means economic relations of suppliers and producers of inputs for agriculture and food industry, problems from the aspects of social economy and rural sociology and finally the economics of the population nutrition. Original scientific papers dealing with agricultural subjects from the sphere of economics, management, informatics, ecology, social economy and sociology. The journal is administered by an international Editorial Board.Published since 1954 (by 1999 under the title Zemědělská ekonomika) An international open access peer-reviewed journal published by the Czech Academy of Agricultural Sciences and financed by the Ministry of Agriculture of the Czech Republic.

Shahrzad series 2017 no 7